SCHEMBL20160067

SCHEMBL20160067

Fc1cc(Cl)cc(Oc2nc(I)nn2C2COC2)c1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPAS1 Q99814 2/20 0.33
BTK Q06187 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23504765 0.87 BTK (0.36) EPAS1BTK
SCHEMBL20154264 0.86 EPAS1 (0.34) EPAS1
SCHEMBL20138681 0.77 EPAS1 (0.34) EPAS1BTK
SCHEMBL20159336 0.76 EPAS1 (0.37) EPAS1
SCHEMBL20138707 0.72 BTK (0.36) EPAS1BTK
SCHEMBL23492090 0.69 PSEN1 (0.61)
SCHEMBL23492088 0.69 PSEN1 (0.61)
SCHEMBL23492089 0.69 PSEN1 (0.61)
SCHEMBL20142936 0.68 SOS1 (0.39) BTK
SCHEMBL20139332 0.63 EPAS1 (0.40) EPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018087018-A1 PHENOXYTRIAZOLES F. HOFFMANN-LA ROCHE AG (CH) 2018-05-17 WO disclosed