Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | TAF1 | P21675 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17477291 | 0.78 | KDM4E (0.58) | KDM4EHPGDHSD17B10BRD4MEN1 | |
| SCHEMBL20160225 | 0.75 | SMN1; SMN2 (0.51) | KDM4EHPGDHSD17B10BRD4MEN1 | |
| SCHEMBL4817342 | 0.70 | MAP4K4 (0.38) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL38661026 | 0.67 | PIK3CA (0.41) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL10490635 | 0.64 | KDM4E (0.63) | KDM4EHPGDHSD17B10BRD4ALDH1A1 | |
| SCHEMBL2763151 | 0.63 | KDM4E (0.59) | KDM4EHPGDHSD17B10MEN1KMT2A | |
| SCHEMBL10764328 | 0.63 | KDM4E (0.57) | KDM4EHPGDHSD17B10BRD4MEN1 | |
| SCHEMBL9642720 | 0.59 | LMNA (0.33) | LMNASMN1; SMN2 | |
| SCHEMBL20160357 | 0.59 | SCN5A (0.36) | — | |
| SCHEMBL38664202 | 0.59 | SCN5A (0.36) | KDM4EHPGDHSD17B10ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086585-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |