Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.43 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 7/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160099 | 0.88 | BRD4 (0.47) | BRD4 | |
| SCHEMBL20160341 | 0.85 | BRD4 (0.39) | BRD4 | |
| SCHEMBL20160422 | 0.77 | MAPK14 (0.42) | BRD4MAPK8MAPK14 | |
| SCHEMBL20160005 | 0.77 | BRD4 (0.39) | BRD4 | |
| SCHEMBL20160324 | 0.77 | BRD4 (0.44) | BRD4 | |
| SCHEMBL20160232 | 0.76 | BRD4 (0.39) | BRD4 | |
| SCHEMBL20160096 | 0.74 | BRD4 (0.48) | BRD4 | |
| SCHEMBL20160253 | 0.74 | BRD4 (0.38) | BRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16MAPK14 | |
| SCHEMBL20160319 | 0.74 | BRD4 (0.40) | BRD4 | |
| SCHEMBL20160094 | 0.72 | BRD4 (0.38) | BRD4MAPK8MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086585-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |