Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | DGKZ | Q13574 | 1/20 | 0.33 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4293256 | 0.81 | PIK3CD (0.45) | PIK3CDPRMT5WDR77HRH3MDM2 | |
| SCHEMBL20160951 | 0.81 | PIK3CD (0.45) | PIK3CDPRMT5WDR77HRH3MDM2 | |
| SCHEMBL14924103 | 0.80 | PRMT5 (0.44) | PRMT5WDR77HRH3KDM4ELMNA | |
| SCHEMBL12880866 | 0.77 | HRH3 (0.51) | PRMT5WDR77HRH3SYKALDH1A1 | |
| SCHEMBL13466409 | 0.77 | HRH3 (0.48) | PRMT5WDR77HRH3SYKHTT | |
| SCHEMBL13466407 | 0.77 | ALDH1A1 (0.49) | PRMT5WDR77HRH3ALDH1A1KDM4E | |
| SCHEMBL12880864 | 0.76 | HRH3 (0.53) | PRMT5WDR77HRH3HTTSMN1; SMN2 | |
| SCHEMBL19105585 | 0.74 | PIM1 (0.46) | — | |
| SCHEMBL20804006 | 0.74 | IDH1 (0.38) | PRMT5WDR77HRH3MDM2IDH1 | |
| SCHEMBL12028960 | 0.73 | HRH3 (0.54) | PRMT5WDR77HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086589-A1 | 1,5,7-TRI-SUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES | 上海海雁医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |