Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.42 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27387385 | 0.86 | CFTR (0.53) | CFTRNOTUMP2RX1TMPRSS4SOS1 | |
| SCHEMBL4863532 | 0.85 | CFTR (0.55) | CFTRNOTUMCA12CA1CA2 | |
| SCHEMBL25355994 | 0.83 | CFTR (0.50) | CFTRNOTUMCA12CA1CA2 | |
| SCHEMBL23065961 | 0.82 | NOTUM (0.54) | CFTRNOTUMP2RX1TMPRSS4SOS1 | |
| SCHEMBL12499874 | 0.82 | CFTR (0.65) | CFTRNOTUMP2RX1TSHRGAA | |
| SCHEMBL20160881 | 0.81 | RXRA (0.49) | NOTUMP2RX1TMPRSS4CES2KDM4E | |
| SCHEMBL28165889 | 0.80 | CFTR (0.47) | CFTRNOTUMP2RX1TMPRSS4SOS1 | |
| SCHEMBL12499334 | 0.78 | TDP1 (0.49) | CFTRNOTUMP2RX1LMNATSHR | |
| SCHEMBL422201 | 0.78 | CFTR (0.69) | CFTRNOTUMCA12CA1CA2 | |
| SCHEMBL13280707 | 0.78 | CFTR (0.64) | CFTRNOTUMCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024072178-A1 | COMPOUND FOR TARGETED PROTEIN DEGRADATION, AND USE THEREOF | (주)사이러스테라퓨틱스 | 2024-04-04 | — | — | WO | disclosed |
| WO-2022268229-A1 | PROTEIN INHIBITOR OR DEGRADING AGENT, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND PHARMACEUTICAL USE | 和径医药科技（上海）有限公司 | 2022-12-29 | — | — | WO | disclosed |
| WO-2018086589-A1 | 1,5,7-TRI-SUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES | 上海海雁医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |