Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 16/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20090302 | 1.00 | IRAK4 (0.46) | IRAK4IRAK1GSK3BDYRK1APIK3CD | |
| SCHEMBL30703608 | 1.00 | IRAK4 (0.46) | IRAK4IRAK1GSK3BDYRK1APIK3CD | |
| SCHEMBL20161344 | 0.94 | IRAK4 (0.42) | IRAK4IRAK1GSK3BDYRK1A | |
| SCHEMBL30703606 | 0.94 | IRAK4 (0.42) | IRAK4IRAK1GSK3BDYRK1A | |
| SCHEMBL20090317 | 0.94 | IRAK4 (0.42) | IRAK4IRAK1GSK3BDYRK1A | |
| SCHEMBL20090304 | 0.94 | IRAK4 (0.42) | IRAK4IRAK1GSK3BDYRK1A | |
| SCHEMBL29132893 | 0.90 | IRAK4 (0.43) | IRAK4IRAK1 | |
| SCHEMBL30703612 | 0.90 | IRAK4 (0.43) | IRAK4IRAK1 | |
| SCHEMBL20090309 | 0.90 | IRAK4 (0.43) | IRAK4IRAK1 | |
| SCHEMBL20090337 | 0.90 | IRAK4 (0.44) | IRAK4IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532470-B1 | OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2018089199-A1 | OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION | RIGEL PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |