SCHEMBL20161154

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL20140339	0.92	L3MBTL1 (0.40)	L3MBTL1PDE5ANR1H2NR1H3CYP1A2
	SCHEMBL20139619	0.91	L3MBTL1 (0.45)	L3MBTL1PDE5ACYP1A2CYP3A4CYP2C19
	SCHEMBL20140418	0.89	L3MBTL1 (0.38)	L3MBTL1PDE5AKDM4ECYP1A2CYP3A4
	SCHEMBL20140459	0.89	MAPT (0.43)	L3MBTL1PDE5AMEN1KMT2AALDH1A1
	SCHEMBL20161279	0.89	L3MBTL1 (0.37)	L3MBTL1PDE5AMEN1KMT2A
	SCHEMBL20148909	0.88	L3MBTL1 (0.41)	L3MBTL1PDE5A
	SCHEMBL20148908	0.86	PDE5A (0.51)	PDE5A
	SCHEMBL20139738	0.86	GUCY1A1 (0.35)	L3MBTL1PDE5A
	SCHEMBL20140449	0.85	PDE5A (0.40)	PDE5A
	SCHEMBL20161254	0.85	PDE5A (0.40)	PDE5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.