Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24040791 | 0.89 | PDE5A (0.49) | PDE5AADORA3KCNH2 | |
| SCHEMBL20161089 | 0.89 | ADORA3 (0.53) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140309 | 0.88 | PDE5A (0.55) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140385 | 0.87 | PDE5A (0.52) | PDE5AADORA3KCNH2 | |
| SCHEMBL20161461 | 0.86 | PDE5A (0.50) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140220 | 0.85 | ADORA3 (0.52) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140214 | 0.85 | PDE5A (0.51) | PDE5AADORA3KCNH2 | |
| SCHEMBL20161120 | 0.85 | ADORA3 (0.52) | PDE5AADORA3KCNH2 | |
| SCHEMBL21775383 | 0.85 | PDE5A (0.51) | PDE5AADORA3KCNH2 | |
| SCHEMBL20140423 | 0.85 | PDE5A (0.51) | PDE5AADORA3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |