Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 15/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 15/20 | 0.45 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21787437 | 0.91 | PDE5A (0.43) | GUCY1A1GUCY1B1PDE5AL3MBTL1GSK3B | |
| SCHEMBL21787263 | 0.90 | L3MBTL1 (0.38) | GUCY1A1GUCY1B1PDE5AL3MBTL1 | |
| SCHEMBL20140169 | 0.87 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL24040769 | 0.79 | PDE5A (0.44) | PDE5AL3MBTL1 | |
| SCHEMBL21787225 | 0.79 | L3MBTL1 (0.60) | GUCY1A1GUCY1B1PDE5AL3MBTL1 | |
| SCHEMBL21787236 | 0.78 | L3MBTL1 (0.47) | PDE5AL3MBTL1 | |
| SCHEMBL24205856 | 0.78 | PDE5A (0.45) | PDE5AL3MBTL1 | |
| SCHEMBL21787195 | 0.78 | L3MBTL1 (0.44) | GUCY1A1GUCY1B1PDE5AL3MBTL1 | |
| SCHEMBL21787238 | 0.78 | L3MBTL1 (0.49) | PDE5AL3MBTL1 | |
| SCHEMBL20140411 | 0.78 | L3MBTL1 (0.46) | PDE5AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089330-A2 | SGC STIMULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |