Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | CA9 | Q16790 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | NOXO1 | Q8NFA2 | 1/20 | 0.57 |
| ▸ | TXK | P42681 | 1/20 | 0.56 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 2/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.56 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.56 |
| ▸ | EP300 | Q09472 | 1/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23365942 | 0.92 | CA12 (0.58) | CA12CA1CA2CA9PKM | |
| SCHEMBL23365946 | 0.92 | CA12 (0.58) | CA12CA1CA2CA9PKM | |
| SCHEMBL20161540 | 0.87 | F2 (0.62) | CA12CA1CA2CA9PKM | |
| SCHEMBL23365917 | 0.86 | F2 (0.63) | CA12CA1CA2CA9PKM | |
| SCHEMBL23365916 | 0.85 | F2 (0.60) | PKMNOXO1F2PRSS1PRSS2 | |
| SCHEMBL27089673 | 0.84 | TXK (0.48) | CA12CA1CA2CA9PKM | |
| SCHEMBL19261534 | 0.83 | F2 (0.60) | CA12CA1CA2CA9PKM | |
| SCHEMBL15216220 | 0.82 | F2 (0.73) | CA12CA1CA2CA9PKM | |
| SCHEMBL19017236 | 0.82 | F2 (0.73) | CA12CA1CA2CA9PKM | |
| SCHEMBL19751698 | 0.82 | F2 (0.73) | CA12CA1CA2CA9PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3534899-B1 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS INC (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2018089261-A2 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |