Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24780233 | 0.83 | IRAK4 (0.36) | IRAK4HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL24780232 | 0.83 | IRAK4 (0.38) | IRAK4ALDH1A1ALOX15TSHRSMN1; SMN2 | |
| SCHEMBL30259930 | 0.79 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL24780933 | 0.79 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL20161246 | 0.79 | IRAK4 (0.44) | IRAK4 | |
| SCHEMBL20090319 | 0.79 | IRAK4 (0.40) | IRAK4 | |
| SCHEMBL30703612 | 0.79 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL20090309 | 0.79 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL29132893 | 0.79 | IRAK4 (0.43) | IRAK4 | |
| SCHEMBL20090337 | 0.78 | IRAK4 (0.44) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3532470-B1 | OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |
| WO-2018089199-A1 | OXAZOLE DERIVATIVES FOR USE AS IRAK INHIBITORS AND METHOD FOR THEIR PREPARATION | RIGEL PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |