⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23556321 | 1.00 | — | — | |
| SCHEMBL16122262 | 1.00 | — | — | |
| SCHEMBL15722725 | 0.98 | DPP4 (0.30) | — | |
| SCHEMBL11148793 | 0.79 | — | — | |
| SCHEMBL22249208 | 0.76 | — | — | |
| SCHEMBL20326314 | 0.74 | DRD2 (0.31) | — | |
| SCHEMBL22880761 | 0.74 | DPP4 (0.31) | — | |
| SCHEMBL21794727 | 0.74 | — | — | |
| SCHEMBL15432298 | 0.71 | CYP1A2 (0.38) | — | |
| SCHEMBL20326344 | 0.70 | JAK3 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022265974-A1 | AMINOHETEROCYCLE-SUBSTITUTED TRICYCLIC KRAS INHIBITORS | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022266167-A1 | AMIDE AND UREA-CONTAINING TRICYCLIC KRAS INHIBITORS | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| EP-3534899-B1 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS INC (US) | 2022-06-01 | — | — | EP | disclosed |
| WO-2021127404-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2018089261-A2 | COMPOUNDS AND METHODS FOR MODULATING INTERLEUKIN-2-INDUCIBLE T-CELL KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |