Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 4/20 | 0.33 |
| ▸ | KIF5B | P33176 | 4/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | ETV6 | P41212 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7883028 | 0.92 | DGAT1 (0.41) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL15026290 | 0.91 | CHEK1 (0.40) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL2723620 | 0.90 | DGAT1 (0.43) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL2680276 | 0.90 | CHEK1 (0.41) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL15007294 | 0.89 | DGAT1 (0.39) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL15007528 | 0.89 | DGAT1 (0.39) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL21356 | 0.89 | DGAT1 (0.40) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14298310 | 0.89 | DGAT1 (0.40) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14298078 | 0.89 | DGAT1 (0.40) | DGAT1CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL10327979 | 0.89 | DGAT1 (0.40) | DGAT1CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |