SCHEMBL2016203

SCHEMBL2016203

Cc1c(C(=O)OCc2ccccc2)[nH]c2c1C(=O)CC(c1ccco1)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 12/20 1.00
SMN1; SMN2 Q16637 12/20 1.00
ALDH1A1 P00352 11/20 1.00
PKM P14618 11/20 1.00
L3MBTL1 Q9Y468 10/20 1.00
LMNA P02545 9/20 1.00
HSD17B10 Q99714 7/20 1.00
TSHR P16473 7/20 1.00
TDP1 Q9NUW8 6/20 1.00
NPSR1 Q6W5P4 6/20 1.00
MAPT P10636 6/20 1.00
ESR1 P03372 5/20 1.00
RECQL P46063 4/20 1.00
MEN1 O00255 3/20 1.00
KMT2A Q03164 3/20 1.00
APEX1 P27695 3/20 1.00
ESR2 Q92731 1/20 1.00
HTT P42858 3/20 0.80
ALOX15 P16050 2/20 0.80
MCL1 Q07820 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2016385 0.93 POLB (0.88) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2014912 0.89 POLB (1.00) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2016403 0.87 POLB (0.81) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2016219 0.86 SMN1; SMN2 (0.87) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2016888 0.86 POLB (0.84) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2019581 0.85 POLB (1.00) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2015501 0.85 POLB (1.00) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2016416 0.85 POLB (0.80) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2020480 0.85 ALDH1A1 (1.00) POLBSMN1; SMN2ALDH1A1PKML3MBTL1
SCHEMBL2021255 0.84 POLB (0.83) POLBSMN1; SMN2ALDH1A1PKML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233501-A1 COMPOSITIONS FOR INHIBITING 3' REPAIR EXONUCLEASE 2 AND METHODS OF SCREENING FOR SUCH COMPOSITIONS UNIV TEXAS (US) 2023-07-27 US claimed
US-20200253913-A1 COMPOSITIONS FOR INHIBITING 3' REPAIR EXONUCLEASE 2 AND METHODS OF SCREENING FOR SUCH COMPOSITIONS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2020-08-13 US claimed
US-20200239969-A1 METHODS AND COMPOSITIONS FOR USE OF TREX2 AS DIAGNOSTIC AND PROGNOSTIC MARKER FOR CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2020-07-30 US claimed
WO-2019079255-A1 METHODS AND COMPOSITIONS FOR USE OF TREX2 AS DIAGNOSTIC AND PROGNOSTIC MARKER FOR CANCER BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-04-25 WO claimed
WO-2019079222-A1 COMPOSITIONS FOR INHIBITING 3' REPAIR EXONUCLEASE 2 AND METHODS OF SCREENING FOR SUCH COMPOSITIONS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-04-25 WO claimed
WO-2011073929-A1 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2011-06-23 WO claimed
US-20230233501-A1 COMPOSITIONS FOR INHIBITING 3' REPAIR EXONUCLEASE 2 AND METHODS OF SCREENING FOR SUCH COMPOSITIONS UNIV TEXAS (US) 2023-07-27 US disclosed
US-11612580-B2 Compositions for inhibiting 3′ repair exonuclease 2 and methods of screening for such compositions THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-03-28 US disclosed
US-20200253913-A1 COMPOSITIONS FOR INHIBITING 3' REPAIR EXONUCLEASE 2 AND METHODS OF SCREENING FOR SUCH COMPOSITIONS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2020-08-13 US disclosed
US-20200239969-A1 METHODS AND COMPOSITIONS FOR USE OF TREX2 AS DIAGNOSTIC AND PROGNOSTIC MARKER FOR CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2020-07-30 US disclosed
WO-2019079222-A1 COMPOSITIONS FOR INHIBITING 3' REPAIR EXONUCLEASE 2 AND METHODS OF SCREENING FOR SUCH COMPOSITIONS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-04-25 WO disclosed
WO-2019079255-A1 METHODS AND COMPOSITIONS FOR USE OF TREX2 AS DIAGNOSTIC AND PROGNOSTIC MARKER FOR CANCER BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-04-25 WO disclosed
WO-2011073929-A1 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2011-06-23 WO disclosed
WO-2011073929-A1 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2011-06-23 WO disclosed