Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.63 |
| ▸ | MTOR | P42345 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MLNR | O43193 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | ESR1 | P03372 | 1/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.63 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8238524 | 0.83 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL4732235 | 0.83 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL5029704 | 0.83 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL29757864 | 0.83 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5955564 | 0.82 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8251145 | 0.79 | SLC6A2 (0.76) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Sertraline SCHEMBL23671988 | 0.78 | SLC6A2 (0.74) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Sertraline SCHEMBL3885286 | 0.78 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Sertraline SCHEMBL3856872 | 0.78 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| Sertraline SCHEMBL3947169 | 0.78 | MEN1 (1.00) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904066-B1 | COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS | SUNOVION PHARMACEUTICALS INC (US) | 2018-05-23 | — | — | EP | claimed |