SCHEMBL4732235

SCHEMBL4732235

Clc1ccc(C2CCCc3ccccc32)cc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 13/20 0.57
SLC6A4 P31645 13/20 0.57
SLC6A3 Q01959 13/20 0.57
GID4 Q8IVV7 1/20 0.56
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
NPC1 O15118 1/20 0.54
MLNR O43193 1/20 0.54
NR1I2 O75469 1/20 0.54
ABCB11 O95342 1/20 0.54
ESR1 P03372 1/20 0.54
CYP1A2 P05177 1/20 0.54
CHRM2 P08172 1/20 0.54
CHRM4 P08173 1/20 0.54
ABCB1 P08183 1/20 0.54
ADRB1 P08588 1/20 0.54
CYP3A4 P08684 1/20 0.54
HTR1A P08908 1/20 0.54
CHRM5 P08912 1/20 0.54
ADRA2A P08913 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29757864 1.00 SLC6A2 (0.57) SLC6A2SLC6A4SLC6A3GID4MEN1
SCHEMBL5029704 1.00 SLC6A2 (0.57) SLC6A2SLC6A4SLC6A3GID4MEN1
SCHEMBL8238524 1.00 SLC6A2 (0.57) SLC6A2SLC6A4SLC6A3GID4MEN1
Hydrochloric Acid SCHEMBL5955564 0.98 SLC6A2 (0.56) SLC6A2SLC6A4SLC6A3GID4MEN1
SCHEMBL5709376 0.90 SLC6A2 (0.60) SLC6A2SLC6A4SLC6A3MEN1KMT2A
SCHEMBL6941770 0.87 GID4 (0.56) SLC6A2SLC6A4SLC6A3GID4CYP3A4
SCHEMBL20468142 0.87 GID4 (0.56) SLC6A2SLC6A4SLC6A3GID4CYP3A4
SCHEMBL20162486 0.83 SLC6A2 (0.63) SLC6A2SLC6A4SLC6A3MEN1KMT2A
SCHEMBL20863599 0.82 HAO1 (0.53) SLC6A2SLC6A4SLC6A3GID4ADRA2A
SCHEMBL22319970 0.79 GID4 (0.61) SLC6A2SLC6A4SLC6A3GID4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651590-A2 PROCESS FOR THE PREPARATION OF AN IMINE INTERMEDIATE EGIS GY GYSZERG (HU) 2006-05-03 EP claimed
WO-2005007611-A2 PROCESS FOR THE PREPARATION OF AN IMINE INTERMEDIATE EGIS GYÓGYSZERGYÁR RT (HU) 2005-01-27 WO claimed
WO-2023230308-A1 DEGRADER COMPOUNDS OF QSOX1 mRNA UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2023-11-30 WO disclosed
US-20200253996-A1 TCTP INHIBITING AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES, INFECTIOUS DISEASES, ALLERGIES, INFLAMMATIONS AND/OR ASTHMA UNIVERSITE PARIS-SUD (FR) 2020-08-13 US disclosed
US-20200253996-A1 TCTP INHIBITING AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES, INFECTIOUS DISEASES, ALLERGIES, INFLAMMATIONS AND/OR ASTHMA UNIVERSITE PARIS-SUD (FR) 2020-08-13 US disclosed
US-10611786-B2 Manganese (III) catalyzed C—H aminations THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2020-04-07 US disclosed
WO-2019143920-A1 ORAL DOSAGE FORMS SUNOVION PHARMACEUTICALS INC. (US) 2019-07-25 WO disclosed
US-20190106448-A1 MANGANESE (III) CATALYZED C--H AMINATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2019-04-11 US disclosed
US-20190106448-A1 MANGANESE (III) CATALYZED C--H AMINATIONS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2019-04-11 US disclosed
WO-2019063955-A1 AGENTS INHIBITING TCTP PROTEIN FOR THE TREATMENT OF PROLIFERATIVE DISEASES, INFECTIOUS DISEASES, ALLERGIES, INFLAMMATIONS AND/OR ASTHMA UNIVERSITE PARIS-SUD (FR) 2019-04-04 WO disclosed
WO-2018144385-A1 ENAMIDE PROCESS SUNOVION PHARMACEUTICALS INC. (US) 2018-08-09 WO disclosed
WO-2008065177-A1 PROCESSES FOR PREPARING DESMETHYLSERTRALINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF CEREP (FR) 2008-06-05 WO disclosed
EP-1904045-A1 USE OF 4-(3,4-DICHLORO-PHENYL)-1,2,3,4-TETRAHYDRO-NAPHTALEN-1-YLAMINE FOR TREATING CANCER Anceris (FR) 2008-04-02 EP disclosed
WO-2007006797-A1 USE OF 4-(3,4-DICHLORO-PHENYL)-1,2,3,4-TETRAHYDRO-NAPHTALEN-1-YLAMINE FOR TREATING CANCER ANCERIS (FR) 2007-01-18 WO disclosed
EP-1224159-B1 IMPROVED SYNTHESIS OF RACEMIC SERTRALINE GEA FARMACEUTISK FABRIK AS (DK) 2004-02-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200253996-A1 TCTP INHIBITING AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES, INFECTIOUS DISEASES, ALLERGIES, INFLAMMATIONS AND/OR ASTHMA NR3C1, TSLP, FPR3 SLC6A2 3339/4885SLC6A4 2672/4885SLC6A3 2924/4885
US-10611786-B2 Manganese (III) catalyzed C—H aminations HLCS, NCL, NUDC SLC6A2 2679/4885SLC6A4 4361/4885SLC6A3 3409/4885
US-20190106448-A1 MANGANESE (III) CATALYZED C--H AMINATIONS HLCS, NCL, NUDC SLC6A2 2459/4885SLC6A4 4130/4885SLC6A3 3115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.