Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 3/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164037 | 1.00 | UCHL1 (0.48) | UCHL1USP30PRMT5WDR77ALDH1A1 | |
| SCHEMBL3357225 | 0.96 | UCHL1 (0.52) | UCHL1USP30ALDH1A1KMT2A | |
| SCHEMBL6962727 | 0.96 | UCHL1 (0.52) | UCHL1USP30ALDH1A1KMT2A | |
| SCHEMBL31226584 | 0.86 | PRMT5 (0.41) | UCHL1USP30PRMT5WDR77ALDH1A1 | |
| SCHEMBL31226315 | 0.86 | PRMT5 (0.41) | UCHL1USP30PRMT5WDR77ALDH1A1 | |
| SCHEMBL31226583 | 0.86 | PRMT5 (0.41) | UCHL1USP30PRMT5WDR77ALDH1A1 | |
| SCHEMBL31226242 | 0.85 | USP30 (0.43) | UCHL1USP30ALDH1A1KMT2ANR1H2 | |
| SCHEMBL31226300 | 0.85 | PRMT5 (0.41) | PRMT5WDR77ALDH1A1KMT2ANR1H2 | |
| SCHEMBL31226358 | 0.85 | PRMT5 (0.41) | PRMT5WDR77ALDH1A1KMT2ANR1H2 | |
| SCHEMBL31226629 | 0.83 | USP30 (0.41) | UCHL1USP30ALDH1A1KMT2ANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11452293-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2022-09-27 | — | — | US | disclosed |
| US-20200236936-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2020-07-30 | — | — | US | disclosed |
| US-10667515-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-20190200611-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2019-07-04 | — | — | US | disclosed |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2018-05-24 | — | — | US | disclosed |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10667515-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | AAAS, NANS, CIAPIN1 | UCHL1 3896/4885USP30 3287/4885PRMT5 2196/4885 |
| US-20190200611-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | UCHL1 3896/4885USP30 3287/4885PRMT5 2196/4885 |
| US-20200236936-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | UCHL1 3896/4885USP30 3287/4885PRMT5 2196/4885 |
| US-11452293-B2 | (S)-5-ethynyl-anabasine, derivatives thereof, and related compositions and methods of making and using | AAAS, NANS, CIAPIN1 | UCHL1 3896/4885USP30 3287/4885PRMT5 2196/4885 |
| US-20180139961-A1 | (S)-5-ETHYNYL-ANABASINE, DERIVATIVES THEREOF, AND RELATED COMPOSITIONS AND METHODS OF MAKING AND USING | AAAS, NANS, CIAPIN1 | UCHL1 3896/4885USP30 3287/4885PRMT5 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.