SCHEMBL20164257

SCHEMBL20164257

CCOC(=O)N(C)C(C)CC(C)OC(=O)c1ccc(Cl)cc1

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.45
ALOX15 P16050 1/20 0.45
TSHR P16473 2/20 0.44
UTS2R Q9UKP6 4/20 0.44
GAA P10253 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.40
ALDH1A1 P00352 2/20 0.40
KMT2A Q03164 1/20 0.39
CHRNB2 P17787 1/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA4 P43681 1/20 0.39
TP53 P04637 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20164283 0.88 TSHR (0.50) USP2ALOX15TSHRUTS2RGAA
SCHEMBL18249468 0.87 LMNA (0.42) TSHRGAASMN1; SMN2ALDH1A1KMT2A
SCHEMBL20164234 0.86 USP2 (0.44) USP2ALOX15TSHRUTS2RGAA
SCHEMBL18249462 0.86 ELANE (0.40) GAAALDH1A1TP53MAPT
SCHEMBL18249393 0.85 CYP4F2 (0.43) TSHRSMN1; SMN2ALDH1A1KMT2AMAPT
SCHEMBL18256243 0.82 TSHR (0.41) USP2ALOX15TSHRUTS2RGAA
SCHEMBL20164214 0.81 POLB (0.52) USP2ALOX15TSHRUTS2RSMN1; SMN2
SCHEMBL15233849 0.80 USP2 (0.50) USP2ALOX15TSHRUTS2RGAA
SCHEMBL14690191 0.79 USP2 (0.60) USP2ALOX15TSHRUTS2RGAA
SCHEMBL18759586 0.79 USP2 (0.60) USP2ALOX15TSHRUTS2RGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed