SCHEMBL20164288

SCHEMBL20164288

CCCc1ccc(C(=O)Oc2c(C)cc(C(C)(C)C)cc2C(C)N(C)C(=O)OCC)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.34
NPSR1 Q6W5P4 1/20 0.34
THRB P10828 1/20 0.34
ABCB1 P08183 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
NPC1 O15118 2/20 0.32
ALDH1A1 P00352 2/20 0.32
RAB9A P51151 2/20 0.32
KMT2A Q03164 1/20 0.32
ESRRG P62508 2/20 0.32
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
RXRA P19793 1/20 0.32
RXRB P28702 1/20 0.32
RXRG P48443 1/20 0.32
DRD2 P14416 1/20 0.32
DRD3 P35462 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15535158 0.83 MAPT (0.36) MAPTNPSR1THRBABCB1TAS1R3
SCHEMBL15535156 0.83 MAPT (0.36) MAPTNPSR1THRBABCB1TAS1R3
SCHEMBL20164228 0.82 ABCB1 (0.35) MAPTNPSR1THRBABCB1TAS1R3
SCHEMBL15534430 0.82 MAPT (0.36) MAPTNPSR1THRBABCB1TAS1R3
SCHEMBL20164256 0.81 ABCB1 (0.35) MAPTNPSR1THRBABCB1TAS1R3
SCHEMBL20164300 0.80 ABCB1 (0.38) MAPTNPSR1THRBABCB1LMNA
SCHEMBL15536402 0.78 NPSR1 (0.40) MAPTNPSR1LMNASMN1; SMN2NPC1
SCHEMBL16555964 0.78 NCEH1 (0.43) MAPTNPSR1ABCB1NPC1ALDH1A1
SCHEMBL15535182 0.78 RARB (0.34) MAPTNPSR1THRBLMNASMN1; SMN2
SCHEMBL15535184 0.78 RARB (0.34) MAPTNPSR1THRBLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3298048-B1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA SRL (IT) 2019-07-03 EP disclosed
US-10221256-B2 Catalyst components for the polymerization of olefins BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2019-03-05 US disclosed
US-20180142044-A1 CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS BASELL POLIOLEFINE ITALIA S.R.L. (IT) 2018-05-24 US disclosed