Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21368757 | 0.81 | NPC1 (0.41) | ALDH1A1SMN1; SMN2HPGDTSHRNPC1 | |
| SCHEMBL2442101 | 0.79 | RAB9A (0.44) | ALDH1A1SMN1; SMN2HPGDTSHRDHODH | |
| SCHEMBL6987430 | 0.77 | EPHX1 (0.37) | DHODHNPC1RAB9A | |
| SCHEMBL1515769 | 0.77 | IDO1 (0.46) | HPGDLMNAKDM4ERAB9A | |
| SCHEMBL2439182 | 0.77 | NPC1 (0.40) | ALDH1A1SMN1; SMN2HPGDLMNATSHR | |
| SCHEMBL6192446 | 0.76 | EPHX1 (0.38) | DHODHACACB | |
| SCHEMBL6510867 | 0.76 | RAB9A (0.44) | SMN1; SMN2SLC6A4NPC1RAB9A | |
| SCHEMBL6985435 | 0.76 | EPHX1 (0.39) | ALDH1A1SLC6A4DHODHNPC1RAB9A | |
| SCHEMBL193457 | 0.75 | IDO1 (0.49) | LMNAKDM4E | |
| SCHEMBL8386053 | 0.74 | NPC1 (0.38) | ALDH1A1SLC6A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |