SCHEMBL2016530

SCHEMBL2016530

CN(C(=O)c1cc(Cl)cc(Cl)n1)C(CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.60
HCRTR2 O43614 2/20 0.60
NPC1 O15118 2/20 0.47
RAB9A P51151 2/20 0.47
PADI4 Q9UM07 3/20 0.37
HRH3 Q9Y5N1 2/20 0.36
TMEM97 Q5BJF2 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
TAAR1 Q96RJ0 1/20 0.35
CASP3 P42574 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC7 Q8WUI4 1/20 0.34
HDAC2 Q92769 1/20 0.34
HDAC10 Q969S8 1/20 0.34
HDAC8 Q9BY41 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2053648 1.00 HCRTR1 (0.60) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2013519 0.89 HCRTR1 (0.68) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2049210 0.89 HCRTR1 (0.68) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2017217 0.85 HCRTR1 (0.64) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2013176 0.85 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9A
SCHEMBL2013226 0.85 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9A
SCHEMBL2012310 0.84 HCRTR1 (0.67) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2012235 0.83 HCRTR1 (0.64) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2014316 0.83 HCRTR1 (0.55) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2010539 0.83 HCRTR1 (0.63) HCRTR1HCRTR2NPC1RAB9APADI4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed