Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.67 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2015866 | 0.88 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2013183 | 0.87 | HCRTR1 (0.61) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2016380 | 0.86 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2018296 | 0.86 | HCRTR1 (0.65) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2013416 | 0.86 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2015020 | 0.85 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL6918071 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2013516 | 0.85 | HCRTR1 (0.66) | HCRTR1HCRTR2NPC1RAB9AHTR1A | |
| SCHEMBL2010539 | 0.85 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9AHRH3 | |
| SCHEMBL2016530 | 0.84 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |