Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21542270 | 1.00 | KDM1A (0.44) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL21542268 | 1.00 | KDM1A (0.44) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL21542203 | 1.00 | KDM1A (0.44) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL20182780 | 1.00 | KDM1A (0.44) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL21542209 | 0.86 | KDM1A (0.42) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL20182865 | 0.86 | KDM1A (0.42) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL21542208 | 0.86 | KDM1A (0.42) | KDM1AMAOBEPHX2GRM7SSTR4 | |
| SCHEMBL30799332 | 0.85 | GAA (0.52) | KDM1AMAOBEPHX2SSTR4GAA | |
| SCHEMBL6899464 | 0.83 | EPHX2 (0.43) | KDM1AMAOBEPHX2SSTR4GAA | |
| SCHEMBL3375125 | 0.78 | EPHX2 (0.41) | KDM1AMAOBEPHX2SSTR4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541812-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | Takeda Pharmaceutical Company Limited (JP) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018092921-A1 | MGLUR7 AGONIST COMPOUNDS FOR TREATING MGLUR7- REGULATED DISEASES, DISORDERS, OR CONDITIONS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-05-24 | — | — | WO | disclosed |