Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018305 | 0.83 | SCN9A (0.36) | MAP4K4SCN9ANR1H2NR1H3PIK3CD | |
| SCHEMBL2010638 | 0.78 | MAP4K4 (0.40) | MAP4K4KDM4EPIK3CDPDE4APDE4B | |
| SCHEMBL2013332 | 0.78 | MAP4K4 (0.42) | MAP4K4KDM4EPIK3CDPDE4APDE4B | |
| SCHEMBL2018303 | 0.74 | PIK3CD (0.41) | MAP4K4SCN9ANR1H2NR1H3PIK3CD | |
| SCHEMBL2013344 | 0.73 | MAP4K4 (0.41) | MAP4K4KDM4EABCG2PIK3CDPDE4A | |
| SCHEMBL2013331 | 0.72 | PIK3CD (0.44) | MAP4K4PIK3CDBCL2 | |
| SCHEMBL2010635 | 0.72 | PIK3CD (0.44) | MAP4K4PIK3CDPDE4APDE4BPDE4C | |
| SCHEMBL2041671 | 0.71 | ACLY (0.36) | SCN9A | |
| SCHEMBL12470338 | 0.70 | PIK3CD (0.42) | MAP4K4PIK3CDPDE4APDE4BPDE4C | |
| SCHEMBL15621512 | 0.69 | PIK3CD (0.43) | MAP4K4PIK3CDBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |