Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2702289 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL7065753 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| Lithium Ion SCHEMBL10680313 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL1401014 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL3169148 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| Potassium Ion SCHEMBL9114094 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL7085287 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL10981093 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL291629 | 0.96 | KDM4E (0.47) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 | |
| SCHEMBL6812017 | 0.96 | KDM4E (0.42) | KDM4EALDH1A1HPGDL3MBTL1SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541368-A1 | IMAGEABLE PARTICLES, METHODS OF MAKING AND METHODS OF USE THEREOF | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2019-09-25 | — | — | EP | claimed |
| WO-2018093566-A1 | IMAGEABLE PARTICLES, METHODS OF MAKING AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-05-24 | — | — | WO | claimed |
| EP-3541368-B1 | IMAGEABLE PARTICLES, METHODS OF MAKING AND METHODS OF USE THEREOF | US HEALTH (US) | 2023-07-12 | — | — | EP | disclosed |
| US-11382990-B2 | Imageable polymers, methods of making and methods of use thereof | THE USA, AS REPRESENTED BY THE SECRETARY, DHHS (US) | 2022-07-12 | — | — | US | disclosed |
| US-20200197540-A1 | Imageable Polymers, Methods of Making and Methods of Use Thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2020-06-25 | — | — | US | disclosed |
| EP-3541368-A1 | IMAGEABLE PARTICLES, METHODS OF MAKING AND METHODS OF USE THEREOF | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018093566-A1 | IMAGEABLE PARTICLES, METHODS OF MAKING AND METHODS OF USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11382990-B2 | Imageable polymers, methods of making and methods of use thereof | PUF60, PBRM1, PCBP1 | KDM4E 1954/4885ALDH1A1 4268/4885HPGD 1801/4885 |
| US-20200197540-A1 | Imageable Polymers, Methods of Making and Methods of Use Thereof | PUF60, PBRM1, PCBP1 | KDM4E 1954/4885ALDH1A1 4268/4885HPGD 1801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.