Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.34 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892141 | 0.82 | PIK3CD (0.36) | DGAT1PIK3CAJAK2 | |
| SCHEMBL20162978 | 0.82 | PIK3CD (0.36) | DGAT1PIK3CAJAK2 | |
| SCHEMBL22553893 | 0.66 | DGAT1 (0.35) | MAPTDGAT1 | |
| SCHEMBL20162894 | 0.64 | CYP1A2 (0.41) | — | |
| SCHEMBL4805591 | 0.63 | KDM4E (0.52) | MAPTNPC1 | |
| SCHEMBL18789215 | 0.63 | DGAT1 (0.41) | MAPTDGAT1NPC1 | |
| SCHEMBL12985575 | 0.63 | DGAT1 (0.37) | MAPTDGAT1 | |
| SCHEMBL29736735 | 0.62 | DGAT1 (0.43) | MAPTDGAT1 | |
| SCHEMBL12009966 | 0.62 | DGAT1 (0.43) | MAPTDGAT1 | |
| SCHEMBL30862665 | 0.62 | TDP1 (0.38) | MAPTDGAT1PDE1BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |
| EP-3541390-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation Therapeutics Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |