Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.59 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.50 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168552 | 1.00 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL20168550 | 1.00 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL20168265 | 1.00 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL27284162 | 0.85 | LMNA (0.51) | RECQLKCNQ3KCNQ2LMNAGAA | |
| SCHEMBL27748279 | 0.85 | RECQL (0.56) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL1289727 | 0.80 | RECQL (0.51) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL14244778 | 0.80 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL9416492 | 0.80 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL14244992 | 0.80 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 | |
| SCHEMBL14244825 | 0.80 | RECQL (0.60) | RECQLKCNQ3KCNQ2USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001586-B2 | Alkyl pyrrolopyrimidine analogs and methods of making and using same | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2021-05-11 | — | — | US | disclosed |
| US-11001586-B2 | Alkyl pyrrolopyrimidine analogs and methods of making and using same | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2021-05-11 | — | — | US | disclosed |
| US-20200062764-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2020-02-27 | — | — | US | disclosed |
| US-20200062764-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2020-02-27 | — | — | US | disclosed |
| EP-3541391-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | The University of North Carolina at Chapel Hill (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094227-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11001586-B2 | Alkyl pyrrolopyrimidine analogs and methods of making and using same | TYRO3, MERTK, LCK | RECQL 4184/4885KCNQ3 3916/4885KCNQ2 4042/4885 |
| US-20200062764-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | TYRO3, MERTK, LCK | RECQL 4184/4885KCNQ3 3916/4885KCNQ2 4042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.