⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327122 | 1.00 | — | — | |
| SCHEMBL327121 | 1.00 | — | — | |
| SCHEMBL6873315 | 1.00 | — | — | |
| SCHEMBL8143836 | 1.00 | — | — | |
| SCHEMBL12763448 | 0.90 | GABRR1 (0.52) | — | |
| SCHEMBL24242945 | 0.86 | GABRR1 (0.45) | — | |
| SCHEMBL9244510 | 0.86 | GABRR1 (0.45) | — | |
| SCHEMBL9990687 | 0.86 | GABRR1 (0.45) | — | |
| SCHEMBL1934966 | 0.86 | GABRR1 (0.45) | — | |
| SCHEMBL12032751 | 0.86 | GABRR1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321100-A1 | CD73 INHIBITOR AND APPLICATION THEREOF IN MEDICINE | BETTA PHARMACEUTICALS CO., LTD (CN) | 2023-10-12 | — | — | US | disclosed |
| CN-111819173-B | CD73 inhibitors | 伊莱利利公司 | 2023-06-06 | — | — | CN | disclosed |
| EP-3759096-B1 | CD73 INHIBITORS | LILLY CO ELI (US) | 2022-02-16 | — | — | EP | disclosed |
| US-11028074-B2 | CD73 inhibitors | ELI LILLY AND COMPANY (US) | 2021-06-08 | — | — | US | disclosed |
| US-11028074-B2 | CD73 inhibitors | ELI LILLY AND COMPANY (US) | 2021-06-08 | — | — | US | disclosed |
| US-11001586-B2 | Alkyl pyrrolopyrimidine analogs and methods of making and using same | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2021-05-11 | — | — | US | disclosed |
| US-20210002257-A1 | CD73 INHIBITORS | ELI LILLY AND COMPANY | 2021-01-07 | — | — | US | disclosed |
| CN-111819173-A | CD73 inhibitor | 伊莱利利公司 | 2020-10-23 | — | — | CN | disclosed |
| US-20200062764-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2020-02-27 | — | — | US | disclosed |
| EP-3541391-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | The University of North Carolina at Chapel Hill (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094227-A1 | ALKYL PYRROLOPYRIMIDINE ANALOGS AND METHODS OF MAKING AND USING SAME | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2018-05-24 | — | — | WO | disclosed |
| US-9403806-B1 | Cognition enhancing compounds and compositions, methods of making, and methods of treating | NEUROSOLIS, INC. (US) | 2016-08-02 | — | — | US | disclosed |