Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | NT5E | P21589 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29493242 | 0.88 | ADORA3 (0.58) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20180326 | 0.88 | ADORA3 (0.58) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20180115 | 0.86 | NT5E (0.59) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20167946 | 0.86 | ADORA3 (0.64) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20168620 | 0.84 | ADORA1 (0.62) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL21750381 | 0.84 | NT5E (0.57) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20168548 | 0.83 | ADORA3 (0.60) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20168771 | 0.82 | NT5E (0.68) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL21766007 | 0.81 | ADORA3 (0.60) | ADORA3ADORA1ADORA2AADORA2BMEN1 | |
| SCHEMBL20180112 | 0.79 | NT5E (0.60) | ADORA3ADORA1ADORA2AADORA2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541396-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | Arcus Biosciences, Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |