Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.54 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.54 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20651355 | 0.90 | SPHK1 (0.65) | SPHK1SPHK2ASAH2CTSKPPARG | |
| SCHEMBL15259087 | 0.90 | SPHK1 (0.65) | SPHK1SPHK2ASAH2CTSKPPARG | |
| SCHEMBL23519395 | 0.89 | SPHK1 (0.64) | SPHK1SPHK2ASAH2CTSKPPARG | |
| SCHEMBL20609508 | 0.88 | ASAH2 (0.43) | SPHK1SPHK2ASAH2PPARA | |
| SCHEMBL20168989 | 0.83 | SPHK1 (0.77) | SPHK1SPHK2ASAH2TRPA1TRPM2 | |
| SCHEMBL20651197 | 0.79 | SPHK1 (0.47) | SPHK1SPHK2ASAH2 | |
| SCHEMBL15259085 | 0.79 | SPHK1 (0.47) | SPHK1SPHK2ASAH2 | |
| SCHEMBL13896118 | 0.77 | SPHK1 (0.65) | SPHK1SPHK2ASAH2TRPA1TRPM2 | |
| SCHEMBL20651207 | 0.76 | SPHK1 (0.74) | SPHK1SPHK2ASAH2TRPA1TRPM2 | |
| SCHEMBL12450362 | 0.76 | SPHK1 (0.74) | SPHK1SPHK2ASAH2TRPA1TRPM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974758-B2 | Sphingosine kinase type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |