Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.77 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.38 |
| ▸ | TRPM2 | O94759 | 3/20 | 0.38 |
| ▸ | ASAH2 | Q9NR71 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | TACR2 | P21452 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13896120 | 0.88 | SPHK1 (0.83) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL20596127 | 0.87 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL20592376 | 0.87 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL120911 | 0.87 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18194573 | 0.87 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL14633002 | 0.87 | SPHK1 (1.00) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23519479 | 0.86 | SPHK1 (0.97) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL20168979 | 0.85 | SPHK1 (0.56) | SPHK1SPHK2ASAH2 | |
| SCHEMBL20168978 | 0.83 | SPHK1 (0.54) | SPHK1SPHK2CYSLTR2CYSLTR1TRPM2 | |
| SCHEMBL12813113 | 0.82 | SPHK1 (0.77) | SPHK1SPHK2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11737992-B2 | Sphingosine kinase Type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20210177776-A1 | SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF | ENZO THERAPEUTICS, INC. (US) | 2021-06-17 | — | — | US | disclosed |
| US-9974758-B2 | Sphingosine kinase type 1 inhibitors and uses thereof | ENZO THERAPEUTICS, INC. (US) | 2018-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210177776-A1 | SPHINGOSINE KINASE TYPE 1 INHIBITORS AND USES THEREOF | SPHK1, SPHK2, S1PR1 | SPHK1 1/4885SPHK2 2/4885CYP3A4 4674/4885 |
| US-11737992-B2 | Sphingosine kinase Type 1 inhibitors and uses thereof | SPHK1, SPHK2, S1PR1 | SPHK1 1/4885SPHK2 2/4885CYP3A4 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.