Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 17/20 | 0.71 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17882185 | 0.91 | RIPK1 (0.71) | RIPK1CES2CES1 | |
| SCHEMBL29638052 | 0.83 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL17874115 | 0.83 | RIPK1 (1.00) | RIPK1 | |
| SCHEMBL19448806 | 0.82 | RIPK1 (0.56) | RIPK1CES2CES1 | |
| SCHEMBL29912731 | 0.77 | RIPK1 (0.76) | RIPK1CES2CES1 | |
| SCHEMBL17882414 | 0.77 | RIPK1 (0.76) | RIPK1CES2CES1 | |
| SCHEMBL17882181 | 0.75 | RIPK1 (0.72) | RIPK1 | |
| SCHEMBL29912938 | 0.75 | RIPK1 (1.00) | RIPK1CES2CES1 | |
| SCHEMBL17882413 | 0.75 | RIPK1 (1.00) | RIPK1CES2CES1 | |
| SCHEMBL19448802 | 0.74 | RIPK1 (0.76) | RIPK1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974762-B2 | Necrosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-05-22 | — | — | US | disclosed |