Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 15/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20169357 | 0.92 | DGAT1 (0.49) | DGAT1 | |
| SCHEMBL20169345 | 0.92 | DGAT1 (0.53) | DGAT1CYP3A4HSD17B10KDM4EALDH1A1 | |
| SCHEMBL20169336 | 0.91 | DGAT1 (0.63) | DGAT1 | |
| SCHEMBL9936473 | 0.89 | DGAT1 (0.65) | DGAT1 | |
| SCHEMBL20169344 | 0.86 | DGAT1 (0.50) | DGAT1CYP3A4HSD17B10KDM4EALDH1A1 | |
| SCHEMBL20169383 | 0.84 | DGAT1 (0.51) | DGAT1 | |
| SCHEMBL20169343 | 0.83 | DGAT1 (0.53) | DGAT1PTGS1PTGS2 | |
| SCHEMBL20169376 | 0.82 | DGAT1 (0.51) | DGAT1PTGS1PTGS2 | |
| SCHEMBL20169350 | 0.82 | DGAT1 (0.53) | DGAT1PTGS1PTGS2 | |
| SCHEMBL20169311 | 0.82 | DGAT1 (0.48) | DGAT1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975871-B2 | Continuous arycyclic compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2018-05-22 | — | — | US | disclosed |