Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 11/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18594669 | 0.88 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL15836282 | 0.83 | HCRTR1 (0.49) | HCRTR1HCRTR2CASP6KDM4E | |
| SCHEMBL1586269 | 0.81 | NAPRT (0.49) | HCRTR1HCRTR2CASP6KDM4E | |
| SCHEMBL16148475 | 0.81 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL17069782 | 0.80 | HCRTR1 (0.47) | HCRTR1HCRTR2 | |
| SCHEMBL16025411 | 0.80 | HCRTR1 (0.46) | HCRTR1HCRTR2CASP6KDM4E | |
| SCHEMBL19287257 | 0.79 | PDK2 (0.42) | HCRTR1HCRTR2KDM4E | |
| SCHEMBL18163368 | 0.79 | HCRTR1 (0.46) | HCRTR1HCRTR2CASP6KDM4E | |
| SCHEMBL20169441 | 0.76 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL19484901 | 0.74 | HCRTR1 (0.56) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975876-B2 | 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-05-22 | — | — | US | disclosed |