Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20911215 | 0.85 | NPC1 (0.48) | HCRTR1HCRTR2TRPM8PLK1L3MBTL1 | |
| SCHEMBL18594642 | 0.85 | HCRTR1 (0.42) | HCRTR1HCRTR2TRPM8PLK1L3MBTL1 | |
| SCHEMBL17069771 | 0.83 | HCRTR1 (0.41) | HCRTR1HCRTR2TRPM8PLK1L3MBTL1 | |
| SCHEMBL17071983 | 0.82 | HCRTR1 (0.40) | HCRTR1HCRTR2TRPM8PLK1L3MBTL1 | |
| SCHEMBL18594659 | 0.81 | RAB9A (0.46) | HCRTR1HCRTR2PLK1L3MBTL1LMNA | |
| SCHEMBL20169425 | 0.79 | DPP4 (0.44) | HCRTR1HCRTR2DPP4OPRK1 | |
| SCHEMBL17071972 | 0.77 | HCRTR1 (0.42) | HCRTR1HCRTR2TRPM8PLK1L3MBTL1 | |
| SCHEMBL17723708 | 0.77 | NPC1 (0.48) | HCRTR1HCRTR2TRPM8PLK1L3MBTL1 | |
| SCHEMBL20169442 | 0.76 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL20928592 | 0.76 | L3MBTL1 (0.42) | TRPM8L3MBTL1OPRK1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975876-B2 | 2-pyridyloxy-3-ester-4-ether orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2018-05-22 | — | — | US | disclosed |