Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20364366 | 0.90 | MAPT (0.41) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL20364368 | 0.87 | MAP3K5 (0.40) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL20162154 | 0.84 | MAP3K5 (0.37) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL20364367 | 0.82 | ESR2 (0.41) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL721062 | 0.82 | ESR2 (0.48) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL20364335 | 0.82 | MAP3K5 (0.38) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL20364365 | 0.82 | MAP3K5 (0.36) | ESR2MAP3K5NR1H2MAPTGRAMD1A | |
| SCHEMBL20364348 | 0.80 | MAP3K5 (0.41) | ESR2MAP3K5GCK | |
| SCHEMBL20364356 | 0.80 | MAP3K5 (0.41) | ESR2MAP3K5MAPK1 | |
| SCHEMBL722429 | 0.79 | ESR2 (0.49) | ESR2NR1H2MAPTGRAMD1ADDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323809-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2018-05-23 | — | — | EP | disclosed |