Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 9/20 | 0.41 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20364356 | 0.92 | MAP3K5 (0.41) | MAP3K5TAS2R8RIPK1MKNK1ESR2 | |
| SCHEMBL20367218 | 0.90 | KDM4C (0.42) | MAP3K5 | |
| SCHEMBL20364347 | 0.90 | TAS2R8 (0.49) | MAP3K5TAS2R8KDM1AMKNK1THRB | |
| SCHEMBL20364350 | 0.90 | TAS2R8 (0.49) | MAP3K5TAS2R8KDM1AESR2 | |
| SCHEMBL20364335 | 0.86 | MAP3K5 (0.38) | MAP3K5TAS2R8RIPK1ESR2GCK | |
| SCHEMBL20364368 | 0.85 | MAP3K5 (0.40) | MAP3K5TAS2R8ESR2GCK | |
| SCHEMBL20364352 | 0.85 | MAP3K5 (0.52) | MAP3K5 | |
| SCHEMBL20364355 | 0.85 | TAS2R8 (0.47) | MAP3K5TAS2R8KDM1ARIPK1CDK5 | |
| SCHEMBL20364334 | 0.83 | MAP3K5 (0.43) | MAP3K5TAS2R8KDM1ARIPK1MKNK1 | |
| SCHEMBL20364349 | 0.83 | MKNK1 (0.42) | MAP3K5KDM1AMKNK1GCKCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194773-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2018-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194773-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | NR0B1, NR2E1, NR0B2 | MAP3K5 3026/4885TAS2R8 2479/4885KDM1A 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.