Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599253 | 0.93 | SIGMAR1 (0.37) | OPRL1GPR84SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20103409 | 0.89 | ESR1 (0.39) | OPRL1GPR84SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20975790 | 0.85 | OPRL1 (0.39) | OPRL1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL16962250 | 0.81 | SLC6A2 (0.49) | OPRL1GPR84SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11831337 | 0.78 | OPRL1 (0.35) | OPRL1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL18295013 | 0.77 | SOS1 (0.40) | OPRL1SLC6A2SLC6A4SLC6A3TRPA1 | |
| SCHEMBL10829892 | 0.77 | SIGMAR1 (0.48) | HTR6SIGMAR1 | |
| SCHEMBL11835240 | 0.75 | OPRL1 (0.39) | OPRL1SLC6A2SLC6A4SLC6A3SIGMAR1 | |
| SCHEMBL16961163 | 0.74 | OPRL1 (0.39) | OPRL1SLC6A2SLC6A4SLC6A3TRPA1 | |
| SCHEMBL20889624 | 0.74 | CYP2A6 (0.42) | OPRL1MEN1KMT2ATRPA1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323809-A1 | BICYCLIC HETEROCYCLIC AMIDE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2018-05-23 | — | — | EP | disclosed |