Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.72 |
| ▸ | EED | O75530 | 4/20 | 0.58 |
| ▸ | RBBP4 | Q09028 | 4/20 | 0.58 |
| ▸ | SUZ12 | Q15022 | 4/20 | 0.58 |
| ▸ | RBBP7 | Q16576 | 4/20 | 0.58 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.49 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30387560 | 0.91 | EZH2 (0.86) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499823 | 0.91 | EZH2 (0.86) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL15490780 | 0.84 | EZH2 (0.89) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL1695425 | 0.84 | EZH2 (1.00) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL1694710 | 0.84 | EZH2 (0.88) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684181 | 0.83 | EZH2 (0.86) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170323 | 0.82 | EZH2 (0.66) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL1695481 | 0.82 | EZH2 (0.85) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684189 | 0.82 | EZH2 (0.84) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684312 | 0.82 | EZH2 (0.84) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |