Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.66 |
| ▸ | EED | O75530 | 2/20 | 0.62 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.62 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.62 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12684020 | 0.91 | EZH2 (0.79) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170109 | 0.90 | EZH2 (0.66) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684478 | 0.88 | EZH2 (0.76) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170071 | 0.87 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684618 | 0.84 | EZH2 (0.79) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12499102 | 0.83 | EZH2 (0.79) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684615 | 0.83 | EZH2 (0.72) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL20170059 | 0.82 | EZH2 (0.72) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684477 | 0.82 | EZH2 (0.75) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL10266369 | 0.81 | EZH2 (0.83) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |