Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 16/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170343 | 0.80 | EZH2 (0.63) | EZH2EZH1 | |
| SCHEMBL12499612 | 0.79 | EZH2 (0.76) | EZH2EZH1 | |
| SCHEMBL30386468 | 0.79 | EZH2 (0.76) | EZH2EZH1 | |
| SCHEMBL20170249 | 0.71 | EZH2 (0.59) | EZH2EZH1 | |
| SCHEMBL18800361 | 0.71 | EZH2 (0.75) | EZH2EZH1 | |
| SCHEMBL10255451 | 0.71 | EZH2 (0.55) | EZH2 | |
| SCHEMBL12683939 | 0.70 | EZH2 (0.73) | EZH2EZH1 | |
| SCHEMBL22517696 | 0.70 | EZH2 (0.54) | EZH2 | |
| SCHEMBL17732385 | 0.69 | EZH2 (0.87) | EZH2HDAC6 | |
| SCHEMBL22517694 | 0.69 | EZH2 (0.71) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |