Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 6/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776593 | 0.76 | CYP3A4 (0.45) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL7103655 | 0.75 | GPR35 (0.52) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL7101305 | 0.72 | ERN1 (0.65) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL15776986 | 0.72 | MAPT (0.47) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL19785896 | 0.72 | CYP3A4 (0.41) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL26626576 | 0.67 | MEN1 (0.39) | ALDH1A1CYP3A4CYP1A2MEN1KMT2A | |
| SCHEMBL31451428 | 0.67 | TSHR (0.47) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL7555323 | 0.67 | TSHR (0.50) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL11615026 | 0.66 | ERN1 (0.51) | ERN1 | |
| SCHEMBL28712131 | 0.66 | ERN1 (0.56) | MAPTALDH1A1KDM4ECYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |