Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 3/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16719059 | 0.83 | MGAT2 (0.34) | SCN9ALPAR1LPAR2SMN1; SMN2PKM | |
| SCHEMBL16730885 | 0.78 | SCN9A (0.38) | SCN9ALPAR1LPAR2SMN1; SMN2LMNA | |
| SCHEMBL20170497 | 0.78 | SCN9A (0.38) | SCN9ALPAR1LPAR2SMN1; SMN2LMNA | |
| SCHEMBL16730892 | 0.77 | OGA (0.35) | SCN9ALPAR1LPAR2SMN1; SMN2PKM | |
| SCHEMBL1000263 | 0.71 | LPAR1 (0.51) | SCN9ALPAR1LPAR2LMNAOGA | |
| SCHEMBL16903932 | 0.68 | POLB (0.53) | SCN9ALPAR1LPAR2SMN1; SMN2LMNA | |
| SCHEMBL1058013 | 0.66 | L3MBTL1 (0.52) | SCN9ALPAR1LPAR2SMN1; SMN2RAB9A | |
| SCHEMBL16720931 | 0.65 | OGA (0.36) | SCN9ALPAR1LPAR2OGA | |
| SCHEMBL16718968 | 0.65 | DRD3 (0.35) | SCN9AIDO1MEN1KMT2A | |
| SCHEMBL16718995 | 0.65 | OGA (0.38) | SMN1; SMN2LMNAOGAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068391-B1 | ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME (US) | 2018-05-23 | — | — | EP | disclosed |