Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 12/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16730893 | 1.00 | SCN9A (0.36) | SCN9ASIGMAR1MEN1KMT2AKCNK3 | |
| SCHEMBL16730881 | 0.92 | SCN9A (0.36) | SCN9ASIGMAR1MEN1KMT2AKCNK3 | |
| SCHEMBL20170497 | 0.87 | SCN9A (0.38) | SCN9ASCN5A | |
| SCHEMBL16730885 | 0.87 | SCN9A (0.38) | SCN9ASCN5A | |
| SCHEMBL18128784 | 0.83 | KCNK3 (0.35) | SIGMAR1MEN1KMT2AKCNK3 | |
| SCHEMBL16731014 | 0.83 | KCNK3 (0.35) | SIGMAR1MEN1KMT2AKCNK3 | |
| SCHEMBL20170445 | 0.82 | PRCP (0.35) | SCN9AMEN1KMT2A | |
| SCHEMBL16718972 | 0.81 | SCN9A (0.31) | SCN9A | |
| SCHEMBL20162455 | 0.81 | SCN9A (0.31) | SCN9A | |
| SCHEMBL16903905 | 0.77 | POLB (0.40) | SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3068391-B1 | ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG | MERCK SHARP & DOHME (US) | 2018-05-23 | — | — | EP | disclosed |