Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.41 |
| ▸ | VSIR | Q9H7M9 | 3/20 | 0.41 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170520 | 0.88 | CD274 (0.50) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL20170558 | 0.88 | CD274 (0.50) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL19969086 | 0.87 | CD274 (0.44) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL20170571 | 0.87 | CD274 (0.49) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL20170572 | 0.87 | CD274 (0.49) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL19413592 | 0.86 | HDAC8 (0.42) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL20170542 | 0.86 | HDAC8 (0.42) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL20170552 | 0.85 | HDAC8 (0.41) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL19984857 | 0.77 | CD274 (0.37) | CD274VSIRPDCD1LG2HDAC8HDAC1 | |
| SCHEMBL19984992 | 0.77 | MAPK1 (0.39) | CD274VSIRPDCD1LG2HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041828-B1 | 1,3,4-OXADIAZOLE AND 1,3,4-THIADIAZOLE DERIVATIVES AS IMMUNOMODULATORS | AURIGENE DISCOVERY TECH LTD (IN) | 2018-05-23 | — | — | EP | disclosed |