Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014030 | 1.00 | HCRTR1 (0.51) | HCRTR1OPRM1OPRK1HTR1A | |
| SCHEMBL18473573 | 0.88 | HCRTR1 (0.49) | HCRTR1OPRM1OPRK1 | |
| SCHEMBL13079206 | 0.79 | OPRM1 (0.43) | HCRTR1OPRM1OPRK1 | |
| SCHEMBL10223933 | 0.76 | HCRTR1 (0.45) | HCRTR1OPRM1OPRK1HTR1A | |
| SCHEMBL18473435 | 0.73 | HCRTR1 (0.42) | HCRTR1OPRM1HTR1A | |
| SCHEMBL20170652 | 0.72 | OPRM1 (0.37) | HCRTR1OPRM1 | |
| SCHEMBL20170728 | 0.72 | OPRM1 (0.37) | HCRTR1OPRM1 | |
| SCHEMBL20170607 | 0.72 | OPRM1 (0.37) | HCRTR1OPRM1 | |
| SCHEMBL20170820 | 0.71 | HCRTR1 (0.46) | HCRTR1OPRM1OPRK1 | |
| SCHEMBL13072118 | 0.70 | OPRM1 (0.50) | HCRTR1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |