Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21202073 | 0.84 | GAA (0.46) | GAAOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL10222581 | 0.84 | OPRM1 (0.48) | GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL18458096 | 0.82 | GAA (0.44) | GAAOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL22058061 | 0.82 | GAA (0.41) | GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL18457572 | 0.79 | GAA (0.42) | GAAOPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL12945149 | 0.78 | GAA (0.36) | GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL12588950 | 0.77 | OPRM1 (0.49) | GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL21202042 | 0.77 | GAA (0.48) | GAAOPRM1OPRD1OPRK1LMNA | |
| SCHEMBL10391150 | 0.74 | GAA (0.52) | GAAOPRM1OPRD1OPRK1 | |
| SCHEMBL18457715 | 0.74 | GAA (0.45) | GAAOPRM1OPRD1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |