Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 7/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170685 | 0.81 | OPRM1 (0.41) | OPRM1HTR1AOPRK1OPRD1MRGPRX2 | |
| SCHEMBL20170729 | 0.81 | OPRM1 (0.41) | OPRM1HTR1AOPRK1OPRD1MRGPRX2 | |
| SCHEMBL20170683 | 0.81 | OPRM1 (0.41) | OPRM1HTR1AOPRK1OPRD1MRGPRX2 | |
| SCHEMBL20170865 | 0.79 | OPRM1 (0.49) | OPRM1HTR1AOPRK1OPRD1MRGPRX2 | |
| SCHEMBL20170730 | 0.79 | OPRM1 (0.49) | OPRM1HTR1AOPRK1OPRD1MRGPRX2 | |
| SCHEMBL20170830 | 0.79 | OPRM1 (0.49) | OPRM1HTR1AOPRK1OPRD1MRGPRX2 | |
| SCHEMBL18457820 | 0.73 | OPRM1 (0.49) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL17284780 | 0.73 | OPRM1 (0.49) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL12960903 | 0.73 | OPRM1 (0.49) | OPRM1OPRK1OPRD1MRGPRX2LMNA | |
| SCHEMBL18457818 | 0.73 | OPRM1 (0.49) | OPRM1OPRK1OPRD1MRGPRX2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |