Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170769 | 1.00 | DRD2 (0.60) | DRD2DRD1KCNH2TBXA2RBCHE | |
| SCHEMBL11926150 | 0.90 | DRD2 (0.59) | DRD2DRD1KCNH2TBXA2RBCHE | |
| SCHEMBL12826508 | 0.87 | DRD2 (0.78) | DRD2DRD1KCNH2BCHEACHE | |
| SCHEMBL12950647 | 0.87 | DRD2 (0.78) | DRD2DRD1KCNH2BCHEACHE | |
| SCHEMBL5108036 | 0.87 | KDM4E (0.55) | DRD2DRD1KCNH2 | |
| SCHEMBL10222659 | 0.87 | DRD2 (0.78) | DRD2DRD1KCNH2BCHEACHE | |
| SCHEMBL20170661 | 0.87 | DRD2 (0.56) | DRD2DRD1KCNH2TBXA2RBCHE | |
| SCHEMBL8764588 | 0.87 | DRD2 (0.56) | DRD2DRD1KCNH2TBXA2RBCHE | |
| SCHEMBL10222658 | 0.87 | DRD2 (0.56) | DRD2DRD1KCNH2TBXA2RBCHE | |
| SCHEMBL8764584 | 0.86 | DRD2 (0.53) | DRD2DRD1KCNH2BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |