Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 15/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 12/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170770 | 1.00 | OPRM1 (0.42) | OPRM1OPRK1OPRD1HTR1AHCRTR1 | |
| SCHEMBL20170812 | 0.86 | OPRM1 (0.45) | OPRM1OPRK1OPRD1 | |
| SCHEMBL20170795 | 0.86 | OPRM1 (0.45) | OPRM1OPRK1OPRD1 | |
| SCHEMBL20170736 | 0.86 | OPRM1 (0.45) | OPRM1OPRK1OPRD1 | |
| SCHEMBL20170734 | 0.86 | OPRM1 (0.45) | OPRM1OPRK1OPRD1 | |
| SCHEMBL20170683 | 0.86 | OPRM1 (0.41) | OPRM1OPRK1OPRD1HTR1A | |
| SCHEMBL20170729 | 0.86 | OPRM1 (0.41) | OPRM1OPRK1OPRD1HTR1A | |
| SCHEMBL20170685 | 0.86 | OPRM1 (0.41) | OPRM1OPRK1OPRD1HTR1A | |
| SCHEMBL20170724 | 0.82 | OPRM1 (0.62) | OPRM1OPRK1OPRD1 | |
| SCHEMBL20170638 | 0.82 | OPRM1 (0.64) | OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |